Simply because it is the first time any important NFL games have been played in months, the opening slate of games is a bettor's dream.
The action kicks off on Thursday when the Bills travel to take on the Rams in a game with some of the closest odds of the week (2.5 points in favour of Buffalo).
However, the Browns-Panthers and Packers-Vikings matchups are extremely tight, with Carolina and Green Bay both being slight 1.5-point favourites.
The weekend's highest spreads are just a touchdown. In Chicago, the 49ers are hefty favourites against the Bears, while the Ravens are favoured to beat the Jets on the road.
The season opener for both Tampa Bay and Dallas will be on Sunday Night Football, with Tom Brady and the Patriots favoured by 2.5 points against Dak Prescott and the Cowboys
NFL Thursday Night Football: Buffalo Bills vs. Los Angeles RamsBills -2.5 at Falcons; Saints -5.5 at 49ers; Bears -10.5 at 49ers.Bengals +7 vs the Steelers, 49ers.